Our team gives you additional information with these nanoindenation application notes on practical cases where our nanoindentation products can be used for specific applications.

The use of the Chiaro nanoindenter in myocardial infarction research

This nanoindentation application note underlines the versatility of the Chiaro Nanoindenter in cardiovascular research.

Myocardial infarction (MI) causes the scarring of the tissue in the myocardium which has stiffer mechanical properties and differential cellular composition compared to the healthy tissue. During MI, cardiomyocytes (CMs) are damaged and replaced by cardiac fibroblasts (CFs) which differentiate into cardiac myofibroblasts (CMFs). 

This process causes remodeling of the surroundings of newly formed CMFs into fibrotic tissue by overproduction of the collagenous extracellular matrix which constricts cardiac function. 

This study aims to investigate the contractile mechanical signal propagation across CM-CMF interface as a model for MI boundary in healthy and heart-attack mimicking matrix stiffness conditions.