ECM Mechanobiology

The extracellular matrix (ECM) provides structural and mechanical support to cells across various tissues. Its mechanical properties, including topography and stiffness, influence cellular behavior and function. Thus, understanding ECM mechanobiology advancements is essential.

Measuring ECM stiffness

Optics11 Life offers a solution for assessing the ECM’s mechanical properties. This technology surpasses traditional methods that rely on indirect measures. It provides researchers with tools to measure the ECM’s mechanical properties, producing data that can serve as mechanical biomarkers for cellular behavior.

We have white papers detailing how researchers use Optics11 Life technology in ECM research. These documents emphasize the technology’s ability to measure the ECM’s stiffness accurately and its impact on organoids. Variations in ECM stiffness influence tissue and organ functionality. Furthermore, Optics11 Life technology applications extend to materials science and engineering, emphasizing the importance of understanding material mechanical properties.

Pavone: Advanced Mechanical Characterization for ECM

Pavone stands as our premier mechanical characterization platform, tailored for the extracellular matrix. The ECM’s mechanical properties and its cellular interactions are fundamental for a comprehensive understanding of tissue mechanobiology. Addressing this, Pavone introduces automated indentation mapping, facilitating in-depth studies of tissues and their mechanobiological interactions with the matrix.

Equipped with advanced automation, Pavone enables researchers to systematically collect data on mechanical properties’ spatial distribution across sample surfaces. Its user-friendly interface caters to researchers across expertise spectrums, reducing the dependency on specialized operators and ensuring reliable mechanical characterization.

Our white papers present real-world applications of Optics11 Life technology in ECM research. These papers underscore the precision of our tools in assessing ECM stiffness and its consequential effects on organoids. Such insights hold significance, given that changes in ECM stiffness can drastically affect in vitro tissue and organ functions. Beyond cellular biology, our technology finds applications in fields like materials science and engineering, emphasizing the importance of understanding material mechanics.

Our team offers detailed insights into our nanoindenters’ applications. These instruments are vital in cancer research and disease modeling. They excel in measuring matrix stiffness, a significant biomarker. This measurement is essential for tracking the progression of various cancers, which impact millions globally.