Fibrosis application note

Fibrosis is a condition characterized by the thickening and scarring of connective tissue, usually as a result of injury. This process can lead to severe complications in organs such as the liver, lungs, and heart. Therefore, understanding and tracking fibrosis progression is paramount in disease modeling.

Measuring matrix stiffness

Our nanoindentors offer a unique solution to this challenge. They allow researchers to measure the mechanical properties of fibrotic tissues, providing valuable data that can serve as mechanical biomarkers for the disease. This is a significant advancement in the field, as traditional methods of assessing fibrosis often rely on invasive procedures or indirect measures.

The application notes we provide delve into practical cases where our nanoindentors have been used in fibrosis research. They highlight how these tools can accurately measure the stiffness of fibrotic tissues and fibroblasts. This information is crucial, as an increase in tissue stiffness is a hallmark of fibrosis progression. Moreover, our nanoindentors are not just limited to fibrosis research. They can be used in a variety of other fields, including materials science and engineering, where understanding the mechanical properties of materials is essential.

Our team is dedicated to providing you with comprehensive information about the practical applications of our nanoindentors. These tools are particularly useful in fibrosis research and disease modeling. One of the key areas where our nanoindentors excel is in measuring the stiffness of fibrotic tissues and fibroblasts. This is crucial in tracking the progression of fibrosis, a disease that affects millions worldwide.

Pavone: high-throughput mechanical characterization platform for fibrotic tissues

The mechanical properties of fibrotic tissues and fibroblasts play a crucial role in understanding the mechanobiology of fibrosis.

The high-throughput mechanical characterization platform PAVONE offers automated indentation mapping for studying fibrosis and mechanobiology to address these challenges.

Pavone’s automation capabilities enable researchers to obtain data on the spatial distribution of mechanical properties across the entire sample surface.  Moreover, its user-friendly interface makes it accessible to researchers with varying levels of expertise, reducing the need for highly skilled operators and ensuring consistent and reliable mechanical characterization results.

Overall, Pavone provides an efficient and accessible tool for studying fibrosis and advancing research in this field, potentially leading to improved therapeutic interventions.