Organoids technical note

Organoids are a significant tool for studying tumor progression and disease modeling due to their ability to emulate the architecture and functionality of real organs at a miniature scale. These lab-grown cellular structures offer a realistic platform to model tumor behavior in specific organs like the liver, lungs, or heart.

Measuring organoid stiffness

In response to the demand for accurate organoid modeling, our nanoindenters present an innovative solution. They equip researchers with the capability to quantify the mechanical properties of organoids, yielding crucial data that may act as mechanical biomarkers for disease states. This marks a significant leap forward, given that conventional approaches for organoid assessment often depend on invasive techniques or indirect estimations.

We offer application notes detailing real-world instances where our nanoindenters have been employed in organoid-based tumor research. Importantly, these notes underline how our tools can precisely measure the rigidity of organoid structures and cells. This data is vital because heightened organoid stiffness often signifies advanced disease progression, akin to increased matrix stiffness in actual tumors. Moreover, the applications of our nanoindenters are not restricted to cancer research. They are also applicable in diverse sectors like materials science and engineering, where the knowledge of material mechanical properties is critical.

Pavone: high-throughput mechanical characterization platform for organoids

Introducing Pavone, our advanced mechanical characterization platform designed specifically for organoid models. The mechanical attributes of organoid tissues and cells are pivotal in uncovering the mechanobiology of tumor-like structures. To tackle these issues, Pavone delivers automated indentation mapping for comprehensive organoid and mechanobiology studies.

Pavone’s automation features allow researchers to gather information on the spatial variation of mechanical properties across the whole organoid surface. Additionally, its intuitive interface is accessible to researchers with different skill levels, reducing the requirement for highly trained operators and guaranteeing consistent and dependable mechanical characterization results.

Our supplied technical notes provide real-world examples where our nanoindenters have been utilized in organoid research. These documents emphasize how our tools can accurately quantify the stiffness of organoid tissues and cells. This data is vital since an increase in organoid stiffness is often indicative of advanced disease progression, mirroring the increase in matrix stiffness in actual tumors. Beyond organoid research, our nanoindenters have utility in various other fields, including materials science and engineering, where understanding the mechanical attributes of materials is crucial.

Our team is dedicated to supplying exhaustive information regarding the practical applications of our nanoindenters. These instruments are incredibly advantageous in cancer research and disease modeling using organoids. A standout area where our nanoindenters demonstrate their utility is in gauging organoid stiffness as a biomarker. This is pivotal in monitoring the progression of diverse cancer types, illnesses that impact millions globally.