Yashjit Gangopadhyay

Exploring the Role of Mechanical Forces and the Potential of Nanoindentation for Monitoring and Accelerating the Healing Process

Wounds arise from various causes, including surgery, injury, extrinsic factors (e.g., pressure, burns, and cuts), or illnesses like diabetes and vascular diseases 1. Mechanical forces play an essential role in wound healing. The wound site’s mechanical environment affects cell activity and the quality of wound healing 2. Defects involving healing tissue result in fibrotic scars …

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Controlling vascular remodeling with Pavone Nanoindenter

Researchers at the University of Twente (Netherlands) have designed advanced growth factor-delivering systems to mimic angiogenesis. To provide long-term functionality to the designed vasculature, they enhanced the spatial and temporal control over the vascular endothelial growth factor (VEGF) within the 3D microenvironment to guide the vascular remodeling processes. Controlling cellular fate and functionality by modulating …

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Hydrogel mechanics are a key driver in bioengineering

Hydrogels, a versatile class of biomaterials, play a central role in bioengineering and regenerative medicine. They are a three-dimensional (3D) network of hydrophilic polymers made from natural and synthetic polymers or a combination of both 1,2. Hydrogels’ mechanical properties can be adjusted across a wide range, allowing them to guide cell function and tissue development …

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Cell mechanical properties as a new biomarker for cancer

Cancer is among the leading causes of death worldwide, accounting for nearly 10 million deaths in 2020, or almost one in six. The most common causes of cancer death in 2022 were lung (1.80 million deaths), colon and rectum (916.000 deaths), liver (830.000 deaths), stomach (769.000 deaths), and breast (685.000 deaths).  Cancer arises from the …

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Mechanobiology of fibrotic-related diseases

Fibrotic diseases and tumor-associated fibrosis constitute a worldwide health problem that, together, are responsible for enormous morbidity and mortality. Approximately 1 in 8 people worldwide suffer from fibrotic-related diseases. Fibrotic diseases encompass a broad spectrum of clinical disorders, including systemic sclerosis, idiopathic pulmonary fibrosis, macular degeneration, chronic kidney disease, liver cirrhosis, and cardiac fibrosis. Similar …

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Published articles (2022) endorse Optics11 Life’s unique technology.

https://www.optics11life.com/wp-content/uploads/2022/11/ENGINEERED-MARBLE-LIKE-BOVINE-FAT-TISSUE.mp4 Written by Fabiany Da Costa Gonçalves and illustrated by Yashjit Gangopadhyay Studies on the mechanobiology of cells, spheroids, organoids, tissues, and biomaterials are developing rapidly using our Chiaro, Piuma, and Pavone Nanoindenters. Most studies have investigated diseases and new therapies in regenerative medicine. More than 400 publications have cited Optics11 Life Nanoindenters in leading …

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EPIC CEO INTERVIEW: Niek Rijnveld reveals his journey as the CEO of Optics11 Life

EPIC’s Photonics Technologies Program Manager, Antonio Castelo, interviews Niek Rijnveld, CEO of Optics 11 Life Optics11 Life is a fast-growing high-tech company based in Amsterdam that manufactures instruments to measure the forces and mechanical properties of soft materials, including biological samples Summary AMSTERDAM, Q3, 2022 – Optics11 Life was established to commercialize a promising fibre-top sensing …

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Optics11 Life raises €5 million in funding for superior life science instruments 

Funding will support expanded offerings for drug development, and regenerative medicine as fibre-optic instrument-maker broadens their presence in the life science market  The new investment will also bolster the leadership team and support U.S. expansion  AMSTERDAM, September 29, 2022 – Optics11 Life, the fibre optics life science instrumentation company, announced today €5 million in new …

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