Increase clinical success and prevent costly delays
Traditional 2D cell culture systems fail to accurately replicate in vivo conditions, while animal models suffer from species-specific differences and low throughput. These limitations contribute to a high failure rate (90%) of drug candidates in clinical trials*.
Innovative 3D cell culture models, such as tissue-engineered skeletal muscle (TESM), provide a more physiologically relevant environment for studying disease progression and drug target discovery. These models can significantly optimize drug safety and efficacy evaluation at the earliest stages of neuromuscular disorder (NMD) drug development.
References:
* Mullard, Asher. “Parsing clinical success rates.” Nature Reviews Drug Discovery 15.7 (2016): 447-448.
Our experts on solutions for neuromuscular contractility assay are happy to help you with their advice.
Characterization of 3D-TESMs contractile properties upon Electrical Pulse Stimulation. (Left) Frame shots of different time points during live imaging of fluorescence Ca2+ flux. (Right) Overlay of a curve of tetanic contractions recorded with the Cuore (in red), with a curve generated by quantifying the fluorescence signal of Ca2+ flux (green dots).
, , , , , , , , Real-time and Multichannel Measurement of Contractility of hiPSC-Derived 3D Skeletal Muscle using Fiber Optics-Based Sensing. Adv. Mater. Technol. 2023, 8, 2300845. https://doi.org/10.1002/admt.202300845
Enhance and accelerate therapy development for neuromuscular disorders
Generate substantial efficacy & safety data for robust lead selection
Automated in-incubator monitoring of skeletal muscle contractility allows to model NMDs effectively, hence providing a reliant functional human 3D in vitro assay.
Increase preclinical model significance for better therapy- & disease prediction
Integrated electrical muscle stimulation training promotes muscle tissue maturation and allows to model muscle training influence on NMD treatment.
Promote clinical success by modelling genetic diversity
Use iPSC technology or primary-derived stem cells to engineer low-volume TESMs with adequate human complexity.
Trusted by
experts
Alessandro Iuliano
Erasmus MC, Rotterdam
Pim Pijnappel
EMC Rotterdam
Marnix Franken
Leiden University Medical Centre (LUMC)
Why Optics11 Life?
At Optics11 Life, we strive to apply our unique technology to help our customers develop breakthrough medical treatments and get them to patients faster. Our patented fiber optic sensing technology enables precise, quantifiable, and reliable measurements.
Through active collaboration with experts, we are able to translate needs for solutions that address ever-evolving research challenges, into practical, easy-to-use, and scalable laboratory instrumentation. This has resulted in the development of Cuore, the platform for taking muscle contractility research to the next level.
With a highly skilled and specialized global distribution and customer support network, we can effectively support and facilitate our customers in achieving their research objectives.
