tissue mechanicsNanoindenters to measure tissue mechanics
The fields of tissue engineering and regenerative medicine have expanded rapidly over the past decade, paving the road for an all-round revolution of medical treatment. Mechanical properties of cells and tissues have been found to play a key role in many aspects of physiology and disease. However, research is just scratching the surface of mechanical phenotyping, and Optics11 Life has developed powerful nanoindenters to help accelerate discoveries in this field.
Nanoindentation provides a better understanding of cell mechanics and its relation to cell state and function. Also nanoindentation allows the identification of new, significant measurement parameters that can play a major role in drug development, mechanobiology and tissue regeneration. Measuring complex and soft biological samples in hydrated conditions involves many challenges, but our optical fiber-based instruments provide an easy and robust way to gather powerful and significant data.
The technology of Optics11 Life tools is based on two key elements: pre-calibrated, reusable fiber–optic sensors and state-of-the-art mechatronics. This combination allows Optics11 Life to develop cutting-edge, unique nanoindentation systems which are applied successfully in the field of life science. Optics11 Life nanoindenters can measure complex, irregular materials in physiological conditions, analyzing various mechanical properties at once in combination with imaging. These include elasticity (Young’s Modulus) and visco-elasticity (Storage and Loss Moduli) by performing quasi-static or micro-DMA (Dynamic Mechanical Analysis) mechanical tests. Therefore, our revolutionary tools enable new research in the fields of tissue engineering and regenerative medicine, where mechanical properties of biomaterials and cells should be similar to the native biological tissues and cells.
The Piuma Nanoindenter can measure the mechanical properties of biomaterials, tissues, hydrogels and other larger soft samples. The samples can be characterized in air and in liquid. The table-top Piuma Nanoindenter is robust and very time-efficient.
The Chiaro nanoindenter is specifically designed for dual-use with any existing microscope. This enables the mechanical characterization of small samples such as cells and micro-particles. The compact Chiaro compact is easy to use but still highly accurate.
The Pavone is the worlds first fully integrated optical imaging, micro-mechanical indentation and incubation platform. The instrument provides a high-throughput solution to obtain larger quantities of datasets on mechanics of living cells and tissues.