Cuore is an all-in-one platform that pairs precise measurement of the force generated by engineered muscle with customizable electrical stimulation, providing valuable biological insights based on contraction dynamics.
Drug development
Assess effects on muscle function for drug efficacy and safety in physiologically relevant muscle models.
Disease modelling
Reproduce (patho)physiology using genetically modified cell lines and isogenic controls to assess mutation-specific changes in muscle contractility.
Linking drug efficacy to muscle function
Gain insights into the functional impact of next-generation therapies, including gene and RNA-based treatments, by assessing how they influence muscle performance
Manual analysis is a thing of the past. With Cuore, all key contraction dynamics are automatically quantified, so you can focus on interpreting results instead of processing data.
Cuore extracts a wide range of parameters from each contraction. These can be used to calculate advanced metrics like:
Whether you’re running short-term tests or long-term studies, Cuore gives you the data you need to quantify muscle performance with confidence
At the core of Cuore is our unique optical fiber sensing technology, which captures even the smallest changes in contractility with high precision. We provide a direct force readout unlike any other system. The platform can run reliably in any incubator for up to months. This ensures the stable conditions you expect in standard cell culture.
With integrated electrical stimulation, you can precisely control your experiments to compare multiple test groups side by side in a reliable manner. With our platform, you can automate exercise protocols and run up to 96 parallel conditions (4 × 24-well plates) side by side.
Watch this short video to learn more about Cuore.
Cuore is designed for 3D engineered muscle bundles in both skeletal and cardiac applications. It works with iPSC-derived, immortalized, and primary cells.
To develop effective therapies, researchers need models that reflect real human physiology and allow functional evaluation through contraction. Cuore’s pillar-based 3D tissue model replicates the structure and function of human muscle tissue, offering a clear advantage over 2D cultures and animal models (Iuliano et al., 2023).
This combination of biological relevance and functional readout makes Cuore a powerful tool for drug development, disease modelling, and next-generation therapy evaluation.
600 000 cells per engineered muscle bundle
0 – 100 Hz per well
capacity 24 × 4 wells = 96 tissues
Ready for use with incubator
Brightfield + fluorescence (inverted)
1 – 4200 µN
1 – 15 kHz (4 samples in parallel)
0 – 25 mA per sample
(± 12 V)
17.5 × 15.3 × 5.2 cm
(L x W x H)
Reusable & autoclavable
600 000 cells per engineered muscle bundle
0 – 100 Hz per well
capacity 24 × 4 wells = 96 tissues
Ready for use with incubator
Brightfield + fluorescence (inverted)
1 – 5 400 µN
1 – 15 kHz (4 samples in parallel)
0 – 50 mA per sample (± 12 V)
17.5 × 15.3 × 5.2 cm
(L x W x H)
Reusable & autoclavable
We understand that you need to know if Cuore fits your specific research. Our team has experience across a range of disease areas, including:
We’ve contributed to studies on drug responses, exercise effects, and other functional outcomes. If you get in touch, we would be happy to share our insights and discuss how Cuore could support your application.
Whether your focus lies on mechanical measurements and characterization at the cell scale, or you work with muscle tissues, our platforms offer you precise, fast, and accurate outcomes. Discover more about how our products can help you accelerate and achieve your research goals.
With a wide range of application areas, across an array of samples, for various disease areas and testing needs, we can provide you with precise insights into mechanical cues to advance your translational research. Learn more about our applications here.
We are a growing team of 60+ passionate people, headquartered in Amsterdam, the Netherlands. Learn more about our journey so far, meet our team of professionals, and our career opportunities.
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