Written by Fabiany Da Costa Gonçalves and illustrated by Yashjit Gangopadhyay
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Studies on the mechanobiology of cells, spheroids, organoids, tissues, and biomaterials are developing rapidly using our Chiaro, Piuma, and Pavone Nanoindenters.
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Most studies have investigated diseases and new therapies in regenerative medicine. More than 400 publications have cited Optics11 Life Nanoindenters in leading scientific journals.
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The publication rate has increased significantly since 2015. In 2022 alone, we appeared in 82 publications.
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Check out the list of new publications from 2022 and the different applications of the Chiaro, Piuma, and Pavone Nanoindenters.
1. Cells
No.
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Type
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Keywords
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Author
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1.1
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Multi-cellular
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cell polarization, aggregates
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cellular aggregates
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1.2
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Embryo
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keratin filaments, embryonic membranes
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1.3
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Epithelial cells
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mechanoresponse, monolayers, 3D microwells
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monolayers, hexanematic crossover
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RhoA autoregulation, apical microvilli
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cortical tension, desmosomal morphogenesis
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substrate stiffness, apical-basal polarization, renal
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cell signalling, corneal
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1.4
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Hepatocytes
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extracellular matrix, iPSC-derived phenotype
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1.5
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Endothelial cells
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vascular self-assembly, 3D printing
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stiffness sensing, smooth muscle cells
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proinflammatory response, smooth muscle cells
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1.6
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Neurons
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neuronal viscoelasticity
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1.7
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Cardiomyocytes
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3D scroll wave chaos, deep neural networks
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contractile dysfunction, extracellular stiffness
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microtubules, tubulin detyrosination
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1.8
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Fibroblasts
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vaginal fibroblast, polyisocyanides, in-vitro model
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soft substrates, fibroblast reprogramming
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non-muscle myosin, durotaxis
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1.9
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Myocytes
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myocyte mechanics, atomic force microscopy
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myonuclear re-modelling
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1.10
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Cartilage
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regeneration, BMSCs
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non-surgical recontouring, auricular cartilage
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1.11
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Stem cells
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bone marrow, mesenchymal stem cells, polymer, hydrogel
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cancer cell monolayers, mesenchymal stem cells
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mechanosensitivity, aging, muscle stem cell
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Exploring the Role of Mechanical Forces and the Potential of Nanoindentation for Monitoring and Accelerating the Healing Process
Wounds arise from various causes, including surgery, injury, extrinsic factors (e.g., pressure, burns, and cuts), or illnesses like diabetes and vascular diseases 1. Mechanical forces
Controlling vascular remodeling with Pavone Nanoindenter
Researchers at the University of Twente (Netherlands) have designed advanced growth factor-delivering systems to mimic angiogenesis. To provide long-term functionality to the designed vasculature, they
Hydrogel mechanics are a key driver in bioengineering
Hydrogels, a versatile class of biomaterials, play a central role in bioengineering and regenerative medicine. They are a three-dimensional (3D) network of hydrophilic polymers made
Cell mechanical properties as a new biomarker for cancer
Cancer is among the leading causes of death worldwide, accounting for nearly 10 million deaths in 2020, or almost one in six. The most common
Mechanobiology of fibrotic-related diseases
Fibrotic diseases and tumor-associated fibrosis constitute a worldwide health problem that, together, are responsible for enormous morbidity and mortality. Approximately 1 in 8 people worldwide
Published articles (2022) endorse Optics11 Life’s unique technology.
https://www.optics11life.com/wp-content/uploads/2022/11/ENGINEERED-MARBLE-LIKE-BOVINE-FAT-TISSUE.mp4 Written by Fabiany Da Costa Gonçalves and illustrated by Yashjit Gangopadhyay Studies on the mechanobiology of cells, spheroids, organoids, tissues, and biomaterials are developing
2. Tissues
No.
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Type
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Keywords
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Author
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2.1
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Cardiac tissue
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cardiac fibrosis, organ-on-chip, iPSC cardiomyocytes
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drug screening, scanning electrochemical microscpoy
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2.2
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Eyes (ocular)
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retinal ganglion cell, lamina cribrosa, extracellular matrix
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corneal epithelium, diabetic retinopathy, retinoic acid
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2.3
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Liver
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liver stiffness, single cell biomechanics, NAFLD
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2.4
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Kidney
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diabetic kidney disease, fibrosis, matrix stiffness
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2.5
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Nerve
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nerve regeneration, micropatterns, peptide gradient
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2.6
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Carotid plaque
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viscoelasticity, kelvin-voigt fractional derivative (KVFD)
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3. Others
No.
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Type
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Keywords
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Author
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---|---|---|---|
3.1
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Spheroids
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mechanically tunable biomimetic hydrogel, MSCs
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3D cell cultures, hydrogels, multicellular spheroids
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tunable hydrogel, multicellular spheroids
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3.2
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Organoids
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HIC organoids, hydrogel, ECM
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MDCK cell sheet, 3D deformation, neural organoids
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3.3
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Microenvironment
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extracellular microenvironment, ECM, YAP activation
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ECM, fibroblasts, vascular ehlers-danlos syndrome
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neuroblastoma, ECM, YAP activation
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micromechanics, mechanical characterisation
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3.4
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Tumour
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Adenocarcinoma, 3D cell culture models, ECM
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tumour microenvironment, cellular spheroids, hepatic fibrosis
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breast cancer, gene expression, ECM, cell signalling
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tumor-like microcapsules
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3.5
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Contact Lens
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Delefilcon A, kalifilcon A
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