Published articles (2022) endorse Optics11 Life's unique technology.

Written by Fabiany Da Costa Gonçalves and illustrated by Yashjit Gangopadhyay

Studies on the mechanobiology of cells, spheroids, organoids, tissues, and biomaterials are developing rapidly using our Chiaro, Piuma, and Pavone Nanoindenters.
Most studies have investigated diseases and new therapies in regenerative medicine. More than 400 publications have cited Optics11 Life Nanoindenters in leading scientific journals.
The publication rate has increased significantly since 2015. In 2022 alone, we appeared in 82 publications.
Check out the list of new publications from 2022 and the different applications of the Chiaro, Piuma, and Pavone Nanoindenters.

"The Pavone allows us to perform accurate mechanical measurements on spherical micrometer-sized materials, which has always been true challenge with other techniques..."

1. Cells

No.	Type	Keywords	Author
1.1	Multi-cellular	cell polarization, aggregates	Liu et al., 2022
		cellular aggregates	Oriola et al., 2022
1.2	Embryo	keratin filaments, embryonic membranes	Nahaboo et al., 2022
1.3	Epithelial cells	mechanoresponse, monolayers, 3D microwells	Luciano et al., 2022
		monolayers, hexanematic crossover	Eckert et al., 2022
		RhoA autoregulation, apical microvilli	Lombardo et al., 2022
		cortical tension, desmosomal morphogenesis	Moch et al., 2022
		substrate stiffness, apical-basal polarization, renal	Hagelaars et al., 2022
		cell signalling, corneal	Segars et al., 2022
1.4	Hepatocytes	extracellular matrix, iPSC-derived phenotype	Duda et al., 2022
1.5	Endothelial cells	vascular self-assembly, 3D printing	Duda et al., 2022
		stiffness sensing, smooth muscle cells	Swiatlowska et al., 2022
		proinflammatory response, smooth muscle cells	Wang et al., 2022
1.6	Neurons	neuronal viscoelasticity	Kayal et al., 2022
1.7	Cardiomyocytes	3D scroll wave chaos, deep neural networks	Lebert et al., 2022
		contractile dysfunction, extracellular stiffness	Vite et al., 2022
		microtubules, tubulin detyrosination	Salomon et al., 2022
1.8	Fibroblasts	vaginal fibroblast, polyisocyanides, in-vitro model	Gudde et al., 2022
		soft substrates, fibroblast reprogramming	Xu et al., 2022
		non-muscle myosin, durotaxis	Hakeem et al., 2022
1.9	Myocytes	myocyte mechanics, atomic force microscopy	Peyronnet et al., 2022
		myonuclear re-modelling	Battey et al., 2022
1.10	Cartilage	regeneration, BMSCs	Hou et al., 2022
		non-surgical recontouring, auricular cartilage	Black et al., 2022
1.11	Stem cells	bone marrow, mesenchymal stem cells, polymer, hydrogel	Costa et al., 2022
		cancer cell monolayers, mesenchymal stem cells	Lin et al., 2022
		mechanosensitivity, aging, muscle stem cell	Haroon et al., 2022

Exploring the Role of Mechanical Forces and the Potential of Nanoindentation for Monitoring and Accelerating the Healing Process

29/03/2023 No Comments

Wounds arise from various causes, including surgery, injury, extrinsic factors (e.g., pressure, burns, and cuts), or illnesses like diabetes and vascular diseases 1. Mechanical forces

Controlling vascular remodeling with Pavone Nanoindenter

22/02/2023 No Comments

Researchers at the University of Twente (Netherlands) have designed advanced growth factor-delivering systems to mimic angiogenesis. To provide long-term functionality to the designed vasculature, they

Hydrogel mechanics are a key driver in bioengineering

07/02/2023 No Comments

Hydrogels, a versatile class of biomaterials, play a central role in bioengineering and regenerative medicine. They are a three-dimensional (3D) network of hydrophilic polymers made

Cell mechanical properties as a new biomarker for cancer

14/12/2022 No Comments

Cancer is among the leading causes of death worldwide, accounting for nearly 10 million deaths in 2020, or almost one in six. The most common

Mechanobiology of fibrotic-related diseases

22/11/2022 No Comments

Fibrotic diseases and tumor-associated fibrosis constitute a worldwide health problem that, together, are responsible for enormous morbidity and mortality. Approximately 1 in 8 people worldwide