Researchers at the University of Twente (Netherlands) have designed advanced growth factor-delivering systems to mimic angiogenesis. To provide long-term functionality to the designed vasculature, they enhanced the spatial and temporal control over the vascular endothelial growth factor (VEGF) within the 3D microenvironment to guide the vascular remodeling processes. Controlling cellular fate and functionality by modulating the local availability of VEGF within engineered tissues provides unique opportunities for manipulating cell behavior.
In this advanced study, Rouwkema et al. used Optics11 Life Pavone Nanoindenter to investigate the micromechanical behavior of the 3D matrix, a cell-instructive polymer. In this sense, Pavone supports the development of delivery systems, polymers, scaffolds, hydrogels, and other biomaterials. Besides, Pavone identifies the mechanical properties of biomaterials, the impact of biomaterial mechanical properties on cell behavior, and the role of mechanical stimulation in cell-seeded biomaterials. Therefore, controlling and understanding the mechanical interactions between cells and biomaterials with Pavone can unlock novel therapeutic strategies.